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Flu is rising rapidly, driven by a new variant. Here’s what to know

Only about 28 percent of Iowans have been vaccinated this year, compared to 36 percent who were vaccinated at the same time last year

Clinic support supervisor May Fengmei Lin, CMA, displays a syringe of the Fluarix flu vaccine at International Community Health Services, Wednesday, Sept. 10, 2025, in Seattle. (AP Photo/Lindsey Wasson)
Clinic support supervisor May Fengmei Lin, CMA, displays a syringe of the Fluarix flu vaccine at International Community Health Services, Wednesday, Sept. 10, 2025, in Seattle. (AP Photo/Lindsey Wasson)

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WASHINGTON (AP) — Flu is rising rapidly across the U.S., driven by a new variant of the virus — and cases are expected to keep growing with holiday travel.

That variant, known as “subclade K,” led to early outbreaks in the United Kingdom, Japan and Canada. In the U.S., flu typically begins its winter march in December. On Tuesday, the Centers for Disease Control and Prevention reported high or very high levels of illness in more than half the states.

The CDC estimated there have been at least 7.5 million illnesses, 81,000 hospitalizations and 3,100 deaths from flu so far this season. That includes at least eight child deaths — and is based on data as of Dec. 20, before major holiday gatherings.

A report from the Iowa Department of Health and Human Services for the week ending Dec. 20 flagged high influenza activity in the state, with the number of cases this flu season jumping from 50 to 88. Five Iowans have died from influenza so far this flu season.

Some states are particularly hard-hit. New York’s health department said the week ending Dec. 20 marked the most flu cases the state had recorded in a single week since 2004: 71,000.

It’s far too soon to know if this flu season will be as severe as last winter’s.

But it’s not too late to get a flu shot, which health experts say can still prevent severe illness even if someone gets infected. While this year’s vaccine isn’t a perfect match to the subclade K strain, a preliminary analysis from the U.K. found it offered at least partial protection, lowering people’s risk of hospitalization.

According to the CDC, only about 42 percent of adults and children have gotten a flu vaccination so far this year.

Iowa’s rates are far lower. Only 27.9 percent of Iowans have been vaccinated for influenza this year compared to the 35.6 percent who were vaccinated at the same time last year.

What is subclade K flu?

The flu virus is a shape-shifter, constantly mutating, and it comes in multiple forms. There are two subtypes of Type A flu, and subclade K is a mutated version of one of them, named H3N2. That H3N2 strain is always harsh, especially for older adults.

Subclade K’s mutations aren’t enough of a change to be considered an entirely new kind of flu.

But they’re different enough to evade some of the protection from this year’s vaccine, said Andrew Pekosz, a virus expert at Johns Hopkins Bloomberg School of Public Health.

Will subclade K make people sicker?

The CDC said it’s too soon to know how severe this season will be.

Flu seasons dominated by any version of H3N2 tend to be bad, with more infections overall and more people becoming seriously ill. But Hopkins’ Pekosz cautioned it will take time to tease apart whether this subclade K version simply spreads more easily or also is more dangerous.

That question aside, the CDC notes there are some prescription medicines to treat flu — usually recommended for people at high risk of complications. But they generally need to be started a day or two after symptoms begin.

Who needs a flu vaccine?

The CDC and major medical societies all recommend a flu vaccine for just about everyone age 6 months and older. Despite lots of recent misinformation and confusion about vaccines, the flu recommendations haven’t changed.

Flu is particularly dangerous for people 65 and older, pregnant women, young children and people of any age who have chronic health problems, including asthma, diabetes, heart disease and weak immune systems.

Childhood flu vaccination rates in Iowa have plummeted over the last five seasons. The number of Iowa schools where at least 10 percent of students are sick rose from 19 to 47 in the most recent HHS report.

While vaccination rates for Iowa seniors are still lower than they were last year, seniors remain the most protected age group in the state since the 2022-2023 flu season.

The vaccines are brewed to protect against three influenza strains. Despite concern over that new H3N2 variant, they appear to be a good match against H1N1 and Type B flu that may also circulate this year, Pekosz said.

There are shots for all ages, as well as the nasal spray FluMist for ages 2 to 49. For the first time this year, some people may be eligible to vaccinate themselves with FluMist at home.

Fern Alling, of The Gazette, contributed to this report.

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