Iowa State (5-3, 4-1) hosts No. 21 Kansas (6-2, 3-2) in a key Big 12 football game Saturday night. Here’s what you need to know.

Iowa State vs. Kansas storylines

3 keys for ISU: Exude efficiency, derail Devin Neal (and company) and lean on the specialists. Here’s the analysis from Rob Gray.

Gameday feature: Iowa State and Kansas share the national spotlight on Saturday night.

What to watch for: The running game looms large for Iowa State against Kansas.

Get to know Kansas: Here are five Kansas players to watch.

Iowa State vs. Kansas predictions

Line: Iowa State -3

Mike Hlas: Iowa State 24, Kansas 17

John Steppe: Kansas 35, Iowa State 30

Jeff Johnson: Iowa State 28, Kansas 20

Rob Gray: Iowa State 31, Kansas 27

Beth Malicki: Kansas 35, Iowa State 31

Todd Brommelkamp: Iowa State 28, Kansas 24

Kickoff time: 6 p.m. (CT)

TV channel: ESPN

Live stream: ESPN.com or ESPN app

TV announcers: Mike Monaco (play-by-play), Robert Griffin III (analyst), Kris Budden (sideline)

Radio: Cyclone Radio Network | The Varsity Network app